Cryotherapy chambers expose users to air cooled to roughly −110°C to −140°C for two to four minutes — the equipment form of whole-body cryotherapy, which has its own entry under Biohacking Methods.
The Cochrane systematic review (2015) reported insufficient evidence to determine whether whole-body cryotherapy reduces muscle soreness or improves recovery after exercise, citing few, small trials at risk of bias. The U.S. Food and Drug Administration's consumer update on whole-body cryotherapy states that the agency has not cleared or approved any such device for treating medical conditions, and that claimed benefits are unproven while risks — including frostbite, burns and oxygen deficiency in nitrogen-cooled chambers — are documented. Research protocols screen participants and strictly limit exposure time.